Published Papers
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1. Hull, A. D., White, C.R., Pearce, W. J. (1994) Endothelium-derived relaxing factor and cyclic-GMP dependent vasorelaxation in human chorionic plate arteries. Placenta 15:365-375
[view Abstract] [download PDF]2. Pearce, W.J., Hull, A.D., Long, D.M., White, C.R. (1994) Effects of maturation on cyclic GMP-dependent vasodilatation in ovine basilar and carotid arteries. Pediatric Research 36:25-33
[view Abstract] [download PDF]3. Pearce, W.J., White, C.R. (1995) Determination of the [cGMP] yielding half-maximal activation of G-kinase in intact ovine basilar arteries. Proceedings of the Western Pharmacological Society 38:55-58
no abstract available [download PDF]4. White, C.R., Pearce, W.J. (1996) Effects of maturation on cyclic GMP metabolism in ovine carotid arteries. Pediatric Research 39:25-31
[view Abstract] [download PDF]5. White, C.R., Hao X., Pearce, W.J. (2000) Effects of maturation on soluble guanylate cyclase activity in ovine cerebral and carotid arteries. Pediatric Research 47:369-375
[view Abstract] [download PDF]6. White, C.R., Haidekker, M., Bao, X, Frangos, J.A. (2001) Temporal gradients in shear stress, but not spatial gradients or steady shear, induce endothelial cell proliferation. Circulation 103:2508-2513
[view Abstract] [download PDF]7. Haidekker, M., White, C.R., L'Heureux, N Frangos, J.A. (2001) Analysis of temporal shear stgress gradients during the onset phase of flow over a backward-facing step. Implications on endothelia cell proliferation. J. Biomech Eng. 123:455-463
[view Abstract] [download PDF]8. White, C.R., Jiang G.L., Frangos, J.A. (2002) Temporal gradients in shear stimulate osteoblastic proliferation via ERK1/2 and retinoblastoma protein. Am J Physiol Endrocrinol Metab 283:E383-E389
[view Abstract] [download PDF]9. Nauli, S., White, C.R., Hull, A.D., Pearce, W.J. (2003) Effects of maturation on cyclic GMP-dependent vasodilatation in ovine posterior communicating and middle cerebral arteries. Biol Neonate. 83:123-135
[view Abstract] [download PDF]
10. Hunter C.J., Blood A.B., White C.R., Pearce W.J., Power G.G. (2003) Role of nitric oxide in hypoxic cerebral vascodilatation in the ovine fetus. Journal of Physiology 549.2, pp. 625633
[view Abstract] [download PDF]11. Gudi S., Huvar I., McKnight J.L., Dusserre N., White C.R., Boss G.R., Frangos J.A. (2003) Rapid activation of Ras by fluid flow is mediated by Gaq and Gbg subunits of heterotrimeric G proteins in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2003;23:994-1000
[view Abstract] [download PDF]12. White C.R., Haidekker MA, Stevens HY, Frangos JA. (2004) Extracellular signal-regulated kinase activation and endothelin-1 production in human endothelial cells exposed to vibration. J Physiol. 555:565-572
[view Abstract] [download PDF]13. Bagi Z, Frangos JA, Yeh JC, White CR, Kaley G, Koller A. (2005) PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stress. Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1590-5.
[download PDF]14. White CR, Hamade MW, Siami K, Chang MM, Mangalwadi A, Frangos JA, Pearce WJ. (2005) Maturation enhances fluid shear-induced activation of eNOS in perfused ovine carotid arteries. Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H2220-7.
[download PDF]15. White CR, Stevens HY, Haidekker M, Frangos JA. (2005) Temporal gradients in shear, but not spatial gradients, stimulate ERK1/2 activation in human endothelial cells. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2350-5.
[download PDF]16. Williams JM, White CR, Chang MM, Injeti ER, Zhang L, Pearce WJ. (2006) Chronic Hypoxic Decreases in Soluble Guanylate Cyclase Protein and Enzyme Activity are Age-Dependent in Fetal and Adult Ovine Carotid Arteries. J Appl Physiol. 2006 Feb 9.
[download PDF]17. Pearce WJ, Williams JM, Hamade MW, Chang MM, White CR. (2006) Chronic hypoxia modulates endothelium-dependent vasorelaxation through multiple independent mechanisms in ovine cranial arteries. Adv Exp Med Biol. 2006;578:87-92.
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Unpublished 1: White, C.R., Loufrani, L., Stevens, H.Y. Jiang, G.L., Frangos, J.A Shear-Induced dissociation of Gaq-PECAM-1 Complexes Localized to the Endothelial Cell-Cell Junction..
In submission to PNAS [view Abstract]
[download pre-press copy of manuscipt]Unpublished 2: Haidekker, M, White, C.R., Frangos, J.A., Fourier spectrum for extreme temporal gradients generated by high-frequency fluid oscillation: Vascular vibrational damage and mechanotransduction.
In preparation